Serum inhibin pro-αC is a tumor marker for adrenocortical carcinomas
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چکیده
منابع مشابه
Is inhibin a serum marker for ovarian cancer?
Research endocrinologists are well aware of inhibin and the family of proteins of which it is a part. Inhibin was discovered almost 70 years ago as a product of the gonads that selectively inhibited the secretion of folliclestimulating hormone (FSH) at the level of the pituitary gland. We now know that inhibin is present in at least two biologically active forms (inhibin A and B) as well as in ...
متن کاملA selective increase in circulating inhibin and inhibin pro-αC at the time of ovulation in the mare.
The relationship between a selective increase in circulating immunoreactive (ir)-inhibin and the time of ovulation was investigated in mares. Concentrations of plasma ir-inhibin were measured every 4 h during the periovulatory period. Inhibin pro-αC, a precursor protein of the inhibin α-subunit, was also measured. The changes in ir-inhibin and inhibin pro-αC in circulation were parallel. Concen...
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Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up perio...
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Background: The present study was carried out on the human population of Kashmir valley to evaluate the status of the biochemical parameters of infected population. Materials and Methods: Blood samples were collected from 514 individuals, 298 (57.97%) males and 216 (42.02%) females, 187 (36.38%) were found sero-positive for human toxocariasis. Results: Alkaline phosphatase level was found highe...
متن کاملInhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Adrenocortical carcinoma (ACC) is a rare, but highly malignant tumor of unknown origin. Inhibin α-subunit (Inha) knockout mice develop ACCs following gonadectomy. In man, INHA expression varies widely within ACC tissues and its circulating peptide inhibin pro-αC has been described as a novel tumor marker for ACC. We investigated whether genetic and epigenetic changes of the INHA gene in human A...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2012
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-11-0693